Can Biologics Treat My Patients with Nasal Polyps?

Nasal polyps, benign growths in the nasal passages and sinuses, can significantly impact the quality of life for patients suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP).

According to a study published in 2022, the prevalence of CRSwNP in the United States is substantial, affecting approximately 1.1% of the adult population.

This condition often leads to nasal congestion, loss of smell, facial pain, and recurrent sinus infections. The first course of treatment usually involves using a nasal corticosteroid spray to help reduce the size of the abnormal growths.

However, this approach primarily delivers treatment to the nasal cavity at the front of the nose rather than reaching deeper into the sinuses where polyps grow.

Consequently, this approach may not be effective in treating the condition, creating a need for new and better treatments like biologics.

Watch the video: Can Biologics Treat My Patients with Nasal Polyps?

How Biologics Work to Treat Nasal Polyps

Biologics represent a promising advancement in treating nasal polyps, particularly for patients who have not responded adequately to conventional therapies such as corticosteroids or surgery.

These drugs are engineered to target specific components of the immune system that contribute to inflammation and polyp formation. This novel class of drugs works by inhibiting cytokines and other inflammatory mediators, thereby reducing inflammation and the size of the nasal polyps.

Benefits of Using Biologics in Treating Nasal Polyps

The benefits of biologics for CRSwNP are well-documented in scientific literature. Some key benefits include:

Reduction in Polyp Size and Nasal Congestion: Clinical trials have demonstrated that biologics can significantly reduce the size of nasal polyps and alleviate nasal congestion, improving nasal airflow and decreasing symptoms.

Improved Quality of Life: Patients treated with biologics often report a marked improvement in their quality of life, including better sleep, reduced facial pain, and enhanced sense of smell.

Reduced Need for Surgery: By effectively controlling polyp growth and inflammation, biologics can decrease the need for repeated surgical interventions required in severe cases of CRSwNP.

Lower Steroid Use: Biologics can reduce reliance on systemic corticosteroids associated with numerous long-term side effects.

FDA-Approved Biologics for Nasal Polyps

Currently, the FDA has approved several biologics for the treatment of nasal polyps:


Dupilumab (Dupixent): Dupilumab is an IL-4 receptor alpha antagonist that inhibits IL-4 and IL-13 signaling, critical drivers of type 2 inflammation. Clinical trials have shown that dupilumab significantly reduces nasal polyp size and congestion scores.

Omalizumab (Xolair): Omalizumab is an anti-IgE antibody that reduces IgE-mediated inflammation. While primarily used for asthma, omalizumab has been approved for CRSwNP, effectively reducing polyp size and improving nasal symptoms.

Mepolizumab (Nucala): Mepolizumab targets IL-5, a cytokine involved in the growth and activation of eosinophils. The FDA approved CRSwNP for treating nasal polyps due to the vast evidence supporting its role in reducing nasal polyp burden and improving sinus symptoms.

These biologics represent a significant shift in the treatment paradigm for CRSwNP, providing options for patients who have exhausted traditional therapies.

Altus Biologics and You – Reshaping the Treatment of Nasal Polyps with Biologics

Partnering with Altus Biologics offers a streamlined, efficient solution to integrate biologic treatments into your practice.

Altus Biologics specializes in setting up and operating in-office biologic suites, allowing you to provide patients with advanced, proven treatments without the administrative burden.

Altus Biologics provides comprehensive solutions, including complete revenue cycle management, patient services such as scheduling and benefits verification, and support to ensure a seamless experience.

By partnering with Altus Biologics, you can focus on delivering high-quality patient care while maximizing practice efficiency and revenue.

Contact us today to learn more about how we can help you provide in-office biologic therapy to your patients.

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